Loren Data's SAM Daily™

SAMDAILY.US - ISSUE OF SEPTEMBER 12, 2026 SAM #9056
SOLICITATION NOTICE

65 -- Assay Service for assessing ADME properties and in vivo PK properties with the selected vendor. ENAMINE US INC

Notice Date

9/10/2026 12:00:00 AM
 

Notice Type

Combined Synopsis/Solicitation
 

NAICS

424690 — Other Chemical and Allied Products Merchant Wholesalers
 

Contracting Office

NATIONAL INSTITUTES OF HEALTH OLAO BETHESDA MD 20892 USA
 

ZIP Code

20892
 

Solicitation Number

75N98026Q01193ENAMINEUSINCPCANIAAA08396
 

Response Due

9/19/2026 6:00:00 AM
 

Archive Date

09/20/2026
 

Point of Contact

Vishnuvajjala Hanumanth Rao
 

E-Mail Address

vishnuh@mail.nih.gov
(vishnuh@mail.nih.gov)
 

Small Business Set-Aside

NONE No Set aside used
 

Description

The Section on Medicinal Chemistry (SMC) develops new molecular entities with implications in improving health and treatment for various metabolic and alcohol associated diseases. To assess the translational potential of novel molecular entities, which would allow us to make decisions to proceed the compounds for further development we utilize multiple derisking assays. These assays comprise of both cell-based (in vitro) testing and then eventually in mice to assess pharmacokinetic parameters to see if the drug is orally available. Request to procure Chemical Reagent (Assay) Development & Laboratory Testing Service SMC to produce grouped ADME assays and perform a Pharmacokinetic study in C57BL6 mice. By including the Caco-2 Permeability Assay in our ADME evaluation it'll accurately predict the oral absorption potential of our compounds. This well-established in vitro model closely mimics the human intestinal epithelium, providing critical insights into a compound�s passive diffusion, active transport, and efflux processes, such as those mediated by P-glycoprotein (P-gp). The data generated from this assay are vital for informing structure-activity relationship (SAR) optimization, improving compound permeability, and reducing transporter-related liabilities that could hinder bioavailability
 

Web Link

SAM.gov Permalink
(https://sam.gov/workspace/contract/opp/cda237d603a841e58a64dfcb661f51e2/view)
 

Place of Performance

Address: Bethesda, MD 20892, USA

Zip Code: 20892

Country: USA
 

Record

SN07966423-F 20260912/260910230052 (samdaily.us)
 

Source

SAM.gov Link to This Notice
(may not be valid after Archive Date)

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