SOLICITATION NOTICE
R -- A study of environmental exposure to perfluorinated substances and cancer risk in California
- Notice Date
- 7/24/2018
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- N02CP85019-45
- Archive Date
- 8/18/2018
- Point of Contact
- Miguel Diaz, Phone: 240-276-5439
- E-Mail Address
-
miguel.diaz@nih.gov
(miguel.diaz@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address: Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E144, Bethesda, MD 20892, UNITED STATES Description: National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Occupational and Environmental Epidemiology Branch (OEEB), plans to procure, on a sole source basis, data coordinating services and support for the California Teachers Study (CTS) from the University of California San Francisco, 3333 California Street, San Francisco, CA 94118. This acquisition will be processed under FAR Part 12 - Acquisition for Commercial Items and will be made pursuant to the authority in FAR 13.106-1 (b)(2) and 13.501-(a)(1) using simplified acquisition procedures for commercial acquisitionist. The North American Industry Classification System code is 541990 and the business size standard is $15.0M. Per- and polyfluoroalkyl substances (PFAS) were once widely used in commercial and industrial applications. These compounds resist degradation in the environment and are detectable in serum in ~98% of the U.S. population. One persistent PFAS, perfluorooctanoic acid (PFOA), is classified by the International Agency for Research on Cancer as a possible human carcinogen based on animal evidence of liver, testicular, and pancreatic tumors. However, many other PFAS with known toxicity have not been evaluated for carcinogenicity. In occupational studies, PFAS have been associated with non-malignant renal disease and risk of kidney cancer. Consumption of contaminated water was predictive of serum PFAS levels in the C8 Study of mid-Ohio Valley residents living near a manufacturing plant, where PFOA exposure was associated with increased risk of kidney and testicular cancers. The C8 Study of a uniquely exposed population is the only U.S. evaluation of environmental PFOA exposure and cancer risk to-date. No U.S. studies have investigated these relationships with PFAS other than PFOA. PFAS enter waterways via their manufacture, use, and disposal. Widespread PFAS contamination of U.S. drinking water supplies is documented, but PFAS are not currently regulated in public drinking water. A biomonitoring study in the California Teachers Study (CTS) cohort demonstrated exposure to multiple PFAS, and serum levels were higher in participants who lived in ZIP codes served by a public water supply with PFAS detections (Hurley et al., 2016). This was the first study to relate PFAS in drinking water with body burden in the general population. The ubiquity and persistence of PFAS exposures and intriguing but limited epidemiologic evidence of their carcinogenicity provides a strong rationale for further cancer studies. The Occupational and Environmental Epidemiology Branch (OEEB) in the Division of Cancer Epidemiology and Genetics (DCEG) in the National Cancer Institute (NCI) conducts studies of cancer and environmental exposures to drinking water contaminants. DCEG intends to investigate ingestion of PFAS in drinking water and cancer risk in the CTS, leveraging its large numbers of incident cancers, residence histories, and biologic samples. This project will lay the groundwork for studies of PFAS exposure through drinking water and cancer risk by developing a PFAS drinking water exposure assessment. To accomplish this, we plan to link participants' historical residence locations with their drinking water source(s). OEEB will develop a predictive model to estimate PFAS exposures from drinking water (e.g., water consumption, local PFAS point sources, source water characteristics) and will validate these estimates using participants' serum measurements. This novel exposure assessment will set the foundation for future prospective analyses of PFAS and cancer risk. The purpose of this procurement is to support the development of a drinking water exposure assessment for a future study of PFAS and cancer risk among CTS participants. Based on published data in a subset of the CTS population (Hurley et al., 2016), the Government expects PFAS exposures are prevalent. Results of this study will increase NCI's understanding of the specific PFAS point sources and exposure duration and frequency that may explain the association between PFAS exposures and cancer risk in the general population. This NCI-funded study within the CTS cohort is being conducted across the state of California. UCSF has extensive and unique experience in California drinking water data and PFAS that is not available from any other source. They are in a unique position to conduct the work because they are experts in the CTS and initiated the original work in PFAS exposures in this cohort that led to the proposed study. The CTS is uniquely suited to this work because the CTS cohort resides across the state of California, where recently published data has indicated PFAS exposures are widespread. Specimens and data from the CTS were collected prospectively before the diagnosis of cancer, making them extremely valuable for research. Unlike many cohorts, the CTS also has fairly complete residential histories, which allows for adequate PFAS exposure assessment infeasible in other studies. Because they previously measured PFAS in serum for other projects, the CTS also already has these data available for epidemiologic analysis. The expertise of the UCSF collaborators and familiarity with the CTS and PFAS data is unique, and their geographic proximity to and familiarity with the study area also make the study feasible in a way not possible to alternative sources for this procurement. UCSF manages and stores the specimens and data for the CTS. Data collected from this study are used by a large number of external investigators for research projects. There is no other source for the CTS data. Through literature searches and ongoing collaborations with epidemiologists, the CTS was identified as the only large general population U.S. cohort located in an area with elevated PFAS exposures that obtained information about the drinking water source at the women's residences and residence duration. UCSF is the sole source of the CTS data to create the specific datasets which NCI requires for analyses. This notice is not a request for competitive quotation. However, if any interested party, especially small business believes it can meet the above requirement, it may submit a proposal or quote for the Government to consider. The response and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 3:00 PM ET, on August 03, 2018. All responses and questions must be via email to Miguel Diaz, Contracting Officer at miguel.diaz@nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must be registered and have valid certification through SAM.GOV and have Representations and Certifications filled out. Reference: N02RC85019-45 on all correspondence.
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